The Don Mills store is better. It is WAY better. It is objectively, definitely, most-assuredly better. Why? Mostly because it's way bigger, and at Anthropologie, that makes a difference. When your aesthetic is about colour and clutter, you need space to show the excess off to its advantage. The Don Mills store has that. The Yorkville store, on the other hand, is woefully crowded and far less appealing to navigate.
The staff is nicer up north too. I'm not sure why. Maybe Yorkvillians are just inherently snootier than the rest of the city (and the stores feel like they have to have the staff to match).
Finally, the Don Mills store has way more clearance products on offer. While the sale sale tables at the downtown location are often picked clean, leaving dregs and broken bits among only few good finds, uptown you'll find plenty of discounted items for sale, and few broken or damaged bits. Best buys from the sale table in my opinion? Quirky accessories and hardware for the home (like drawer pullls). 2 drawer pulls can equal a matching set at a massive discount and stock like this regularly goes on sale to make way for new merchandise but will look relatively timeless in your home.
Anyway, I'm not going to ramble on. My advice is to make the trip uptown if you want to do the Anthropologie thing in Toronto. It's worth it to avoid the disappointment that is downtown.
Anthropologie: Shops at Don Mills
19 Clock Tower Rd
Toronto, ON M3C 0E1
78 Yorkville Ave
Toronto, ON M5R 2C2
* Photos of a few of my favourite products from the Anthropologie website.